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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
18.48
Human Site:
T1473
Identified Species:
40.67
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
T1473
S
F
E
K
E
R
Q
T
E
K
R
V
L
E
T
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
T1473
S
F
E
K
E
R
Q
T
E
K
R
V
L
E
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
I1450
E
Y
C
R
Y
H
E
I
T
Y
V
A
L
V
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
T1472
S
F
E
K
E
R
Q
T
E
K
R
V
L
E
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
T1432
H
F
E
K
E
R
Q
T
E
K
R
V
L
E
S
Chicken
Gallus gallus
XP_421203
1656
188583
T1479
S
F
E
K
D
R
Q
T
E
K
R
I
F
E
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
S1308
I
T
F
M
V
L
V
S
D
K
E
G
N
Y
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
I955
G
E
K
G
S
V
R
I
Q
S
W
E
R
D
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
I1430
I
T
L
S
I
C
D
I
L
V
V
S
V
G
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
L1066
N
L
F
F
Q
V
F
L
T
K
E
N
S
S
G
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
I1468
R
K
Y
K
P
L
K
I
K
K
L
S
T
N
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
6.6
N.A.
93.3
N.A.
N.A.
86.6
73.3
N.A.
6.6
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
100
N.A.
33.3
N.A.
100
N.A.
N.A.
93.3
93.3
N.A.
20
N.A.
N.A.
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% A
% Cys:
0
0
10
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
10
0
10
0
0
0
0
10
0
% D
% Glu:
10
10
46
0
37
0
10
0
46
0
19
10
0
46
0
% E
% Phe:
0
46
19
10
0
0
10
0
0
0
0
0
10
0
0
% F
% Gly:
10
0
0
10
0
0
0
0
0
0
0
10
0
10
10
% G
% His:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% H
% Ile:
19
0
0
0
10
0
0
37
0
0
0
10
0
0
0
% I
% Lys:
0
10
10
55
0
0
10
0
10
73
0
0
0
0
0
% K
% Leu:
0
10
10
0
0
19
0
10
10
0
10
0
46
0
10
% L
% Met:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
0
10
10
10
0
% N
% Pro:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
10
0
46
0
10
0
0
0
0
0
0
% Q
% Arg:
10
0
0
10
0
46
10
0
0
0
46
0
10
0
10
% R
% Ser:
37
0
0
10
10
0
0
10
0
10
0
19
10
10
46
% S
% Thr:
0
19
0
0
0
0
0
46
19
0
0
0
10
0
19
% T
% Val:
0
0
0
0
10
19
10
0
0
10
19
37
10
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
10
10
0
10
0
0
0
0
10
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _